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卞修武

文章来源:病理科 作者:病理科 发布时间:2019-12-06 点击数量:

卞修武,主任医师、教授,博士生导师。1963年出生于安徽寿县。1986年毕业于第叁军医大学临床医学系,1995年获得医学博士学位(病理学专业)。现任第叁军医大学(陆军军医大学)第一附属医院(糖心vlog官网)病理科主任,全军临床病理学研究所(国家临床重点专科)所长,全军病理学重点实验室和肿瘤免疫病理学教育部重点实验室主任

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基本情况

国家杰出青年基金获得者(2007年),教育部“长江学者”奖励计划特聘教授(2009年),国家973计划项目首席科学家(2010~2014年),国家重点领域“肿瘤干细胞研究”创新团队负责人(2012年),国家“万人计划”科技领军人才(2013年)。获得何梁何利基金科学与技术进步奖(2014年)、“求是杰出青年奖”(2008年)和首届全国创新争先奖奖状(2017年)。

担任国际病理学会(滨础笔)中国区分会(颁顿滨础笔)现任主席,中华医学会病理学分会前任主委,中国抗癌协会肿瘤转移专委会候任主委,中国医师协会病理科医师分会副会长,《中华病理学杂志》副总编,《诊断病理学杂志》总编辑,厂颁滨收录期刊Int J Clin Exp Pathol主编和Lab Invest(美-加病理学会会刊)高级副主编,英国奥辞濒惫别谤丑补尘辫迟辞苍大学等大学荣誉教授。

医疗专长

从事临床医学病理诊断和研究工作30年,临床经验丰富,尤其擅长复杂神经肿瘤的病理诊断。创立了全国脑神经病理专业学组,连续15年牵头组织全国神经病理专科医师培训,并开展疑难病理读片,为解决全国神经病理诊断人才匮乏和疑难病理诊断问题作出重要贡献。牵头制定《肿瘤病理规范化诊断标准》等多项行业规范和指南,推动了我国病理诊断的规范化、标准化和精准化。发起和组织中美病理学联合会议,扩大了我国病理学的国际影响力。

科研成果

一、代表性科研成果奖励和学术荣誉(按年份排序;第一完成人):

1.首届“全国创新争先奖”。2017年

2.中国病理医师分会十年发展特殊贡献奖。2016年

3.首批12名“重庆市首席医学专家”。2016年

4.美国临床病理学会(ASCP)和全美华人病理学家协会(CAPA)“Distinguished Pathologist Award”。2015年(波士顿)

5.何梁何利基金“科学与技术进步奖”。2014年

6.“重庆名医奖”。2013年

7.肿瘤血管生成机制及其在抗血管生成治疗中的应用。国家科技进步一等奖,2012年

8.胶质瘤血管生成的细胞与分子机制研究。中华医学科技一等奖,2010年

9.胶质瘤干细胞分选新方法和生物学特性研究。重庆市自然科学一等奖,2009年

10.胶质瘤血管生成的分子机制研究。重庆市自然科学一等奖,2007年

11.中国科协“求是”杰出青年奖,2007

二、代表性学术论文(按年份排序;#通讯作者):

1.    Shi Y, Ping YF, Zhou W, He ZC, Chen C, Bian BS, Zhang L, Chen L, Lan X, Zhang XC, Zhou K, Liu Q, Long H, Fu TW, Zhang XN, Cao MF, Huang Z, Fang X, Wang X, Feng H, Yao XH, Yu SC, Cui YH, Zhang X, Rich JN, Bao S#,Bian XW#. Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth.Nat Commun, 2017, 8: 15080.

2.    Wu HB, Yang S, Weng HY, Chen Q, Zhao XL, Fu WJ, Niu Q, Ping YF, Wang JM, Zhang X, Yao XH#,Bian XW#. Autophagy induced VEGFR-2 activation promotes the formation of vasculogenic mimicry by glioma stem cells.Autophagy, 2017 Aug 16:1-15. [Epub ahead of print]

3.    Shi Y, Zhou W, Cheng L, Chen C, Huang Z, Fang X, Wu Q, He Z, Xu S, Lathia JD, Ping Y, Rich JN,Bian XW#, Bao S#. Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells.Cell Death Differ, 2016, 24(1):167-180.

4.    Ping YF#, Zhang X,Bian XW#. Cancer stem cells and their vascular niche: Do they benefit from each other?Cancer Lett, 2016, 380(2): 561-567.

5.    Shi Y, Ping YF, Zhang X,Bian XW#. Hostile Takeover: Glioma stem cells recruit TAMs to support tumor progression.Cell Stem Cell, 2015, 16(3): 219-220.

6.    Yang Y, Hernandez R, Rao J, Yin L, Qu Y, Wu J, England CG, Graves SA, Lewis CM, Wang P, Meyerand ME, Nickles RJ,Bian XW#, Cai WB#.Targeting CD146 with a64Cu-labeled antibody enables in vivo immunoPET imaging of high-grade gliomas.Proc Natl Acad Sci USA,2015, 112(47): E6525-34

7.    Wang Z, Wang B, Shi Y, Xu C, Xiao HL, Ma LN, Xu SL, Yang L, Wang QL, Dang WQ, Cui W, Yu SC, Ping YF, Cui YH, Kung HF, Qian C, Zhang X#,Bian XW#. miR-20a and miR-106a enhance the invasiveness of human glioma stem cells by directly targeting TIMP-2.Oncogene,2015, 34(11):1407-1419

8.    Shi Y, Chen C, Yu S, Liu Q, Rao J, Zhang HR, Xiao H, Fu TW, Long H, He ZC, Zhou K, Yao XH, Cui YH, Zhang X, Ping YF#,Bian XW#. miR-663 suppresses oncogenic function of CXCR4 in glioblastoma.Clin Cancer Res, 2015, 21(17): 4004-4013.

9.    Zhou ZH, Rao J, Yang J, Wu F, Tan J, Xu SL, Ding Y, Zhan N, Hu XG, Cui YH, Zhang X, Dong W, Liu XD,Bian XW#. SEMA3F prevents metastasis of colorectal cancer by PI3K-AKT-dependent down-regulation of the ASCL2-CXCR4 axis.J Pathol, 2015, 236(4): 467-478.

10.             Wei C, Cao Y, Zheng Z, Guan K, Wang Q, Tai Y, Zhang Y, Ma S, Cao Y, Ge X, Xu C, Li J, Zhu L, Yan H, Ling Y, Song T, Xu Q, Zhang B,Bian XW#, He X#, Zhong H#. Elevated expression of TANK-binding kinase 1 (TBK1) enhances tamoxifen resistance in breast cancer.Proc Natl Acad Sci USA, 2014, 111(5): E601-610.

11.             Shi Y, Chen C, Yu SZ, Jiang T, Liu Q, Xu JL, Zhang HR, Yao XH, He ZC, Ren Y, Cui W, Xu C, Liu L, Cui YH, Zhang X, Ping YF#,Bian XW#. Primate specific miR-663 functions as a tumor suppressor by targeting PIK3CD and predicts the prognosis of human glioblastoma.Clin Cancer Res,2014, 20(7): 1803-1813.

12.             Wang B, Wang Q, Wang Z, JiangJ, YuSC, Ping YF, Yang J,Xu SL, Ye XZ,Xu C,Yang L,Qian C,Wang JM, Cui YH, Zhang X,Bian XW#.Metastatic consequences of immune escape from NK cell cytotoxicity by human breast cancer stem cells.Cancer Res, 2014,74(20): 5746-5757.

13.             Yan GN, Yang L, Lv YF, Shi Y, Shen LL, Yao XH, Guo QN, Zhang P, Cui YH, Zhang X,Bian XW#, Guo DY#. Endothelial cells promote stem-like phenotype of glioma cells through activating Hedgehog pathway.J Pathol, 2014, 234(1):11-22.

14.             Xu C, Xie D, Yu SC, Yang XJ, He LR, Yang J, PingYF, Wang B, Yang L, Xu SL, Cui W, Wang QL, Fu WJ, LiuQ, Qian C, CuiYH, Rich JN, Kung HF,ZhangX#,Bian XW#. β-Catenin/POU5F1/SOX2 transcription factor complex mediates IGF-I receptor signaling and predicts poor prognosis in lung adenocarcinoma.Cancer Res, 2013, 15; 73(10):3181-3189.

15.             Yang L, Ren Y, Yu X, Qian F, Xiao HL, Xu SL,Yang J, Cui W, Liu Q, Wang Z, Guo W, Xiong G, Yang K.Qian C, Zhang X, Zhang P, Cui YH#,Bian XW#. ALDH1A1 defines invasive cancer stem-like cells and predicts poor prognosis in patientswith esophageal squamous cell carcinoma.Modern Pathol, 2013, 27(5): 775-783.

16.             Shan J, Shen J, Liu L, Xia F, Xu C, Duan G, Xu Y, Ma Q, Yang Z, Zhang Q, Ma L, Liu J, Xu S, Yan X, Bie P, Cui Y,Bian XW#,Qian C#. Nanog regulates self-renewal of cancer stem cell through IGF pathway in human hepatocellular carcinoma.Hepatology, 2012, 56(3):1004-1014.

17.             Yu SC, Xiao HL, Jiang XF, Wang QL, Li Y, Yang XJ, Ping YF, Duan JJ, Jiang JY, Ye XZ, Xu SL, Xin YH, Yao XH, Chen JH, Chu WH, Sun W, Wang B, Wang JM, Zhang X,Bian XW#. Connexin 43 reverses malignant phenotypes of glioma stem cells by modulating E-cadherin.Stem Cells, 2012; 30(2):108-120.

18.             Ye XZ, Xu SL, Xin YH, Yu SC, Ping YF, Chen L, Xiao HL, Wang B, Yi L, Wang QL, Jiang XF, Yang L, Zhang P, Qian C, Cui YH,Zhang X#,Bian XW#. Tumor-associated microglia/macrophages enhance the invasion of glioma stem-like cells via TGF-β1 signaling pathway.J Immunol, 2012, 189(1): 444-453.

19.             Wu F, Zhou Q, Yang J, Duan G, Ou J, Zhang R, Pan F, Peng Q, Tan H, Ping YF, Cui Y, Qian C, Yan XC#,Bian XW#.Endogenous axon guiding chemorepulsant Semaphorin-3F inhibits the tumor growth and metastasis of colorectal carcinoma.Clin Cancer Res, 2011, 17(9):2702-2711.

20.             Ping YF, Yao XH, Jiang JY, Zhao LT, Yu SC, Jiang T, Lin MC, Chen JH, Wang B, Zhang R, Cui YH, Qian C, Wang JM,Bian XW#.The chemokine CXCL12 and its receptor CXCR4 promote glioma stem cell-mediated VEGF production and tumour angiogenesis via PI3K/AKT signaling.J Pathol, 2011, 224(3):344-354.

21.             Ping YF,Bian XW#. Contribution of cancer stem cells to neovascularization.Stem Cells, 2011, 29(6):888-894.

22.             Yao XH, Ping YF, Chen JH, Xu CP, Chen DL, Zhang R, Wang JM, Bian XW#. Glioblastoma stem cells produce vascular endothelial growth factor by activation of a G-protein coupled formylpeptide receptor FPR. J Pathol, 2008, 215(4): 369-376.

23.             Yi L, Zhou ZH, Ping YF, Chen JH, Yao XH, Lu JY, Feng H, Wang JM, Bian XW#. Isolation and characterization of stem cell-like precursor cells from primary human anaplastic oligoastrocytoma. Modern Pathol, 2007, 20(10): 1061-1068.

 


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